The Top Cannabis Strains of 2021

By Liam Noonan


Just like fashion, weed strains fluctuate in and out of popularity. Some iconic strains like Northern Lights #5 remain popular no matter what generation. In 2021, any strain with purple in it is heavily sought after, but these tastes vary from state to state. 

In this article, we set out to designate the 10 most popular and best-selling weed strains of 2021. We sifted through dispensary sales data, awards, and customer reviews throughout the U.S. to make our final distinctions. 

That’s enough of the technicalities, let’s get to the fun part.  

1. Wedding Cake

Wedding Cake, sometimes known as Triangle Mints #23 or Pink Cookies, is an Indica-leaning hybrid strain. It’s a cross between Triangle Cookies and Animal Mints, which results in a well-rounded high. Wedding Cake is considered a rare phenotype and is said to be created by the well-known Seed Junky Genetics. Its enticing name stems from the strains usual sprinkling of frosty resin and hints of sweet vanilla in the aroma. 

Wedding cake is one of the highest searched strains on the internet and for good reason. It consistently wins awards and was most recently named the 2019 strain of the year by Leafly. 

“we smoked a gram joint while staring out at the waterfront watching boats and seagulls and jellyfish and other weird creatures. I blanked out for about a minute contemplating whether that jellyfish was really an octopus so yeah. recommend. now we’re eating tacos.” Leafly User Review

2. Biscotti 

Biscotti is an Indica-dominant hybrid strain revered for its potent cerebral high. A cross between Gelato 25 and Sour Florida OG, Biscotti tends to leave you with a full-body buzz combined with a feeling of relaxation and surge of creativity.

Originally bred by Cookies, The THC levels on this one consistently come in above 20%. That could explain one of the reasons it continues to surge in popularity throughout 2021. Biscotti is popular among consumers looking to relieve symptoms related to stress, anxiety, and depression. Users also positively report sweet cookies’ taste with diesel undertones.

“This s***t got me toasty Boasty foasty west coasty with a cherry on top. This s***t got me Humpty Dumpty yooooooo! Straight gasoline baby yummmmmm” – Leafly User Review

3. Zkittlez 

Nope, that’s not a typo. This strain helps you taste the rainbow but runs into trademark issues (hence the spelling). This sweet candy-flavored strain wins high-profile awards almost every year. Its high tends to be calming, but the fruity taste and smell are what really set this strain apart from the rest in the eyes of the consumer. Make sure to pick this one up if it’s available at your local dispensary. 

“Lifted to the Gods ! Never pass up on this strain ! Physical well being , Mental Clarity , Spiritual Purity After some time passed, my hands started shaking and my heart rate increased. Surprisingly, I did not get paranoid or anxious. I was very calm.” –Leafly User Review 

4. GMO Cookies 

GMO Cookies, otherwise known as Garlic Cookies or GMO Garlic Cookies, is an Indica-dominant hybrid with a reputation that matches its potent effects. It’s bred as a cross between Chemdawg and Girl Scout Cookies making it a high-profile strain straight from inception. GMO Cookies rewards customers and patients with a slightly euphoric high that combines a deep body buzz with mind uplifting characteristics. This strain is consistently one of the most sought after and 2021 is no different. 

“Best strain of the new year  imo because it’s really a different kind of terpene profile then most popular strains out now. There’s fuely strains, sweet strains & fruity ones but not a lot of popular strains have the tag of being a “savory smoke” – Leafly User Review

5. Purple Haze 

Purple Haze is an iconic Sativa strain named after the classic Jimi Hendrix song of the same title. We think it lives up to its namesake offering users a dreamy high that’s perfect for sparking creativity and stomping out a bad mood. When it comes to flavors, you’ll notice hints of berry sweetness mixed with earthy undertones. This one is particularly popular in 2021 due in part to its vibrant purple hues once again living up to its name. 

“Took me from down in the dumps to having a cool time. I went on an adventure and met a crawdad. I subsequently made friends with said crawdad. Man I miss Craymond” – Leafly User Review

6. Chemdawg

Chemdawg doesn’t pull any punches as its signature high comes on fast and strong. This OG strain is the original source of icons like sour diesel and OG Kush, but is most well known for it’s pungent diesel smell. This is another strain energizing strain is a popular choice for those seeking a creativity boost or stimulate the mind for conversation. You can’t go wrong with Chemdawg, but its intense effects should be noted and respected by those with lower tolerances. 

“The chem dizzle is such a nice stone.  You might really enjoy simply being with some of your favorite peeps in some mundane situation.” – Leafly User Review

7. Jack Herer 

Jack Herer is a Sativa-dominant weed strain named after the world-renowned cannabis activist and author of “The Emperor Wears No Clothes” This uplifting strain gives out a relaxed body sensation combined with uplifting mental stimulation. One thing you’ll notice on this one is a sharp and spicy pine scent. It continues to win awards and its popularity is just as widespread as ever in 2021. 

“This was one of the most uplifting strains I ever had the pleasure of trying. Had me laughing at a sitcom that didn’t deserve to be laughed at” – Leafly User Review

8. Girl Scout Cookies

Girl Scout Cookies aka GSC is a classic strain among stoner circles that’s made by crossing OG Kush and Durban Poison. Upon ingestion, you’ll pick up on a euphoric wave that calms down into full-body relaxation. You can’t talk about GSC and not mention its tasty profile that’s often described as minty, sweet, and lemony. The strain is so popular in 2021 that there are more variations and crossbreeds than we can keep track of. 

“This is one of my favorite strains!!! I am a daily user and the effects for me are very strong and intense and, very enjoyable. For me, mostly a head high. It makes me talkative, happy, goofy, and generally in good spirits.” – Leafly User Review

9. Grape Ape 

Grape Ape, originally propagated by Apothecary Genetics and Barney’s Farm, is an Indica-leaning strain that crosses Mendocino Purps, Skunk, and Afghani. The end result comes in with a  distinct grape-like smell paired with effects like relaxation and stress relief. This is a great option for when you want to use creativity as a stress outlet. 

“Got up and walked around, everything was just a little giddy and fun. Then the couch lock hit” – Leafly user Review

10. Sour Diesel 

Sour Diesel is a world-renowned strain with a fantastic reputation. Sativa-dominant, it gets its unique characteristics from the alleged parents Chemdawg & SuperSkunk. Those who try it will likely take notice of Sour Diesel’s pungent signature scent.

First rising to popularity sometime in 1990, Sour Diesel, or Sour “D”, has long been one of the best-selling strains on the market, and for good reason. You’ve heard it named dropped by rappers like Wiz Khalifa or on hit shows like Broad City. 


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